Pdcd4 ELISA Kit for Mouse(Mus musculus) | EIAab.comPdcd4 ELISA Kit for Mouse(Mus musculus)

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Pdcd4 (Gene name),

Programmed cell death protein 4 (Protein name ), PDCD4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pdcd4(Ma3;Tis);

Protein name:

Programmed cell death protein 4;

Alternative:

Topoisomerase-inhibitor suppressed protein;Protein MA-3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (via MI domains) with EIF4A1 and EIF4A2 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.

Function:

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.

Subcellular Location:

Nucleus Cytoplasm Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (By similarity). Exported from the nucleus in the absence of serum.

Protein Attributes:

Sequence length:

469

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

469:

GRKRFVSEGD | GGRLKPESY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.1605

Pfam:

PF02847

String:

Q61823

SMR:

Q61823

KEGG:

mmu:18569

Uniprot:

Q61823

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ELISA Kit for Mouse Programmed cell death protein 4

Cat.:

E2393h

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Manual:

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96T

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ELISA Kit for Mouse Programmed cell death protein 4

Cat.:

E2393c

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96T

ELISA Kit for Mouse Programmed cell death protein 4

Cat.:

E2393m

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96T

ELISA Kit for Mouse Programmed cell death protein 4

Cat.:

E2393r

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96T

CLIA Kit for Mouse Programmed cell death protein 4

Cat.:

U2393r

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96T

CLIA Kit for Mouse Programmed cell death protein 4

Cat.:

U2393c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Programmed cell death protein 4

Cat.:

U2393h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Programmed cell death protein 4

Cat.:

U2393m

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96T

Polyclonal Antibody for Mouse Programmed cell death protein 4

Cat.:

P2393Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Programmed cell death protein 4

Cat.:

P2393Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Programmed cell death protein 4

Cat.:

P2393Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Programmed cell death protein 4

Monoclonal Antibody for Mouse Programmed cell death protein 4

Protein for Mouse Programmed cell death protein 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death."
Shibahara K. , Asano M. , Ishida Y. , Aoki T. , Koike T. , Honjo T.
Gene166:297-301(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain: ICR.
tissue: Thymus.
2.

"Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors."
Onishi Y. , Kizaki H.
Biochem. Biophys. Res. Commun.228:7-13(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lymphoma.
3.

"Cloning of the TIS gene suppressed by topoisomerase inhibitors."
Onishi Y. , Hashimoto S. , Kizaki H.
Gene215:453-459(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
4.

"Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus."
Clee S.M. , Yandell B.S. , Schueler K.M. , Rabaglia M.E. , Richards O.C. , Raines S.M. , Kabara E.A. , Klass D.M. , Mui E.T.-K. , Stapleton D.S. , Gray-Keller M.P. , Young M.B. , Stoehr J.P. , Lan H. , Boronenkov I. , Raess P.W. , Flowers M.T. , Attie A.D.
Nat. Genet.38:688-693(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: BTBR T+ tf/J.
5.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Spleen.
tissue: Testis.
6.

"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L. , Muenstermann E. , Schatten R. , Henze S. , Bohn E. , Mollenhauer J. , Wiemann S. , Schick M. , Korn B.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
8.

"The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation."
Yang H.-S. , Jansen A.P. , Komar A.A. , Zheng X. , Merrick W.C. , Costes S. , Lockett S.J. , Sonenberg N. , Colburn N.H.
Mol. Cell. Biol.23:26-37(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH EIF4A1 AND EIF4A2
9.

"The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA."
Boehm M. , Sawicka K. , Siebrasse J.P. , Brehmer-Fastnacht A. , Peters R. , Klempnauer K.-H.
Oncogene22:4905-4910(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis."
Jansen A.P. , Camalier C.E. , Colburn N.H.
Cancer Res.65:6034-6041(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Structural basis for inhibition of translation by the tumor suppressor pdcd4."
Laronde-Leblanc N. , Santhanam A.N. , Baker A.R. , Wlodawer A. , Colburn N.H.
Mol. Cell. Biol.27:147-156(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF 320-469;FUNCTION;INTERACTION WITH EIF4A AND EIF4G;SUBUNIT;MUTAGENESIS OF ASP-414; ASP-418 AND SER-457
12.

"Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A."
Waters L.C. , Veverka V. , Bohm M. , Schmedt T. , Choong P.T. , Muskett F.W. , Klempnauer K.H. , Carr M.D.
Oncogene26:4941-4950(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 319-449;INTERACTION WITH EIF4A1
13.

"Structural basis for translational inhibition by the tumour suppressor Pdcd4."
Loh P.G. , Yang H.S. , Walsh M.A. , Wang Q. , Wang X. , Cheng Z. , Liu D. , Song H.
EMBO J.28:274-285(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 120-469 IN COMPLEX WITH EIF4A1;SUBUNIT;DOMAIN

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